General Information
    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Dr. Eldin W. C. Lim
    • Executive Editor: Mr. Ron C. Wu
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Editor-in-chief
Dr. Eldin W. C. Lim
Dept. of Chemical and Biomolecular Engineering,
National University of Singapore, Singapore
IJCEA 2013 Vol.4 (2): 46-49 ISSN: 2010-0221
DOI: 10.7763/IJCEA.2013.V4.259

Silver 109 Ag Nanoparticles for Matrix-Less Mass Spectrometry of Nucleosides and Nucleic Bases

Joanna Nizioł and Tomasz Ruman
Abstract—The application of new 109AgNPET nanoparticle surface for analysis of nucleosides and nucleic bases is described along with characterization of 109Ag nanoparticles. The nanoparticles allow laser desorption-ionization mass spectrometry analyses of various low molecular weight (LMW) organic compounds. The new method was used for successful determination of thymidine, 5-fluorouracil, 2’-deoxycytidine, cytidine and 2’-deoxyuridine. The mass determination accuracy was in the 1-3 mDa range which confirms identity of the analyte.

Index Terms—Low molecular weight compounds, MALDI, mass spectrometry, matrix-assisted laser desorption-ionization, nanoparticles, SALDI.

The authors are with the Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland (e-mail: tomruman@prz.edu.pl).

[PDF]

Cite:Joanna Nizioł and Tomasz Ruman, "Silver 109Ag Nanoparticles for Matrix-Less Mass Spectrometry of Nucleosides and Nucleic Bases," International Journal of Chemical Engineering and Applications vol. 4, no. 2, pp. 46-49, 2013.

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