Abstract—Heterocyclic compounds and glucose derivatives
play important role in organic chemistry and biological
chemistry for their richc functionality. A facile and convient
protocol had been developed for the synthesis of a series of
novel glucosyl pyrazole derivatives starting from D-glucose.
The protected glucose by O-pivaloyl groups reacted with BTC
and obtained corresponding 2-isocyanate glucose, which
effectively avoid the harsh conditions and highly toxic agents
compared to the traditional method. Glucosyl pyrazole
derivatives were then prepared through the reaction of pyrazole
and its derivatives with 2-isocyanate glucose with good yields.
Index Terms—Heterocycle, glucose, pyrazole, synthesis.
The authors are with the Hangzhou Normal University, Hangzhou
310036 China (e-mail: 584892598@qq.com, 562818116@qq.com,
459209401@qq.com, 1304112697@qq.com, huizheng@hznu.edu.cn).
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Cite:Kui Du, Yi-Jia Mei, Xian-Ting Cao, Peng-Fei Zhang, and Hui Zheng, "The Synthesis of Pyrazole Derivatives Based on Glucose," International Journal of Chemical Engineering and Applications vol. 4, no. 4 pp. 页码, 2013.
