Abstract—The enhancement in bioavailability of the drugs is
one of the most important concerning aspects of the
pharmaceutical industries. Preparation of nanoparticles or
microparticles of these drugs is the newest formulation
strategies. The size and morphology of a drug are affecting
several essential pharmaceutical properties. In general, the
drug delivery system needs narrow particle size distribution
with regular particle shape, particularly, an engineered drug
particles to meet biopharmaceutical and processing needs. An
antisolvent crystallization technique is being used to prepare
nanoparticles or microparticles for poorly water soluble drugs
at research scale. This method has an ability to change the
solid-state properties of pharmaceutical substances including
the modification of crystal formation and particle size
distributions. Therefore, various operating variables and their
effect on the particle size of poorly water soluble drugs in an
anti-solvent crystallization have been reviewed.
Index Terms—Antisolvent, crystallization, poorly water
soluble drugs, ultrasound.
The authors are with the Sardar Vallabhbhai National Institute of
Technology, Surat, Gujrat-395007-India (e-mail: alonare358@gmail. com,
srp@ched.svnit.ac.in, srpatel079@gmail.com).
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Cite:Abhijit A. Lonare and Sanjaykumar R. Patel, "Antisolvent Crystallization of Poorly Water Soluble Drugs," International Journal of Chemical Engineering and Applications vol. 4, no. 5, pp. 337-341, 2013.
