PLGA Nanoparticles Loaded with the Non-Steroid Anti-Inflammatory: Factor Influence Study and Optimization Using Factorial Design - Volume 4 Number 6 (Dec. 2013) - IJCEA
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    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
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Editor-in-chief
Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan
 

IJCEA 2013 Vol.4(6): 369-372 ISSN: 2010-0221
DOI: 10.7763/IJCEA.2013.V4.327

PLGA Nanoparticles Loaded with the Non-Steroid Anti-Inflammatory: Factor Influence Study and Optimization Using Factorial Design

Lynda Lamoudi, Jean Claude Chaumeil, and Kamel Daoud
Abstract—The aim of this study is to develop a polymeric drug delivery system for a non-steroid anti-inflammatory. To achieve this objective, Piroxicam loaded poly (DL-lactide-co-glycolide) (PLGA) nanoparticles were prepared by nanoprecipitation method and characterized. Formulations were prepared by using experimental design to study the effects of process and formulation variables on response of nanoparticle drug loading (TE) and yield of nanoparticles (TP); for all formulations the volume diameter is less than 1 μm. The physical characteristics of PLGA nanoparticles were evaluated using particle size analyzer and a UV–visible spectrophotometer. The results of optimized formulations showed a large yield of nanoparticles about 72%, and a drug loading more than 67%.

Index Terms—PLGA, nanoparticles, nanoprecipitation technique, piroxicam, experimental design.

Lynda Lamoudi and Kamel Daoud are with the Laboratory of Transfer Phenomena, Faculty of Mechanical and Process Engineering, University of Sciences and Technology Houari Boumediene. BP 32 El Alia, Bab Ezzouar, 16111 Algiers, Algéria (e-mail: llamoudi@ usthb.dz, kdaoud@usthb.dz).
Jean Claude Chaumeil is with the University René Descartes. Faculty of Pharmacy, Paris V. France (e-mail: jean-claude.chaumeil @parisdescartes.fr).

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Cite: Lynda Lamoudi, Jean Claude Chaumeil, and Kamel Daoud, "PLGA Nanoparticles Loaded with the Non-Steroid Anti-Inflammatory: Factor Influence Study and Optimization Using Factorial Design," International Journal of Chemical Engineering and Applications vol. 4, no. 6, pp. 369-372, 2013.

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