Abstract—The aim of this study is to develop a polymeric
drug delivery system for a non-steroid anti-inflammatory. To
achieve this objective, Piroxicam loaded poly
(DL-lactide-co-glycolide) (PLGA) nanoparticles were prepared
by nanoprecipitation method and characterized. Formulations
were prepared by using experimental design to study the effects
of process and formulation variables on response of
nanoparticle drug loading (TE) and yield of nanoparticles (TP);
for all formulations the volume diameter is less than 1 μm. The
physical characteristics of PLGA nanoparticles were evaluated
using particle size analyzer and a UV–visible
spectrophotometer. The results of optimized formulations
showed a large yield of nanoparticles about 72%, and a drug
loading more than 67%.
Index Terms—PLGA, nanoparticles, nanoprecipitation
technique, piroxicam, experimental design.
Lynda Lamoudi and Kamel Daoud are with the Laboratory of Transfer
Phenomena, Faculty of Mechanical and Process Engineering, University of
Sciences and Technology Houari Boumediene. BP 32 El Alia, Bab Ezzouar,
16111 Algiers, Algéria (e-mail: llamoudi@ usthb.dz, kdaoud@usthb.dz).
Jean Claude Chaumeil is with the University René Descartes. Faculty of
Pharmacy, Paris V. France (e-mail: jean-claude.chaumeil
@parisdescartes.fr).
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Cite: Lynda Lamoudi, Jean Claude Chaumeil, and Kamel Daoud, "PLGA Nanoparticles Loaded with the Non-Steroid
Anti-Inflammatory: Factor Influence Study and
Optimization Using Factorial Design," International Journal of Chemical Engineering and Applications vol. 4, no. 6, pp. 369-372, 2013.
