Abstract—Cadmium (Cd) is a heavy metal and it was proposed in the formation of Reactive Oxygen Species (ROS) and Advance Glycation End Products (AGEs). The role of Cd induced oxidative stress and glycation in kidney has not been much studied. Thus our study aimed to measure the oxidative stress and glycation in kidney exposed to Cd. The present study was a true experimental study design to examine the impact of Cd exposure in renal rats (
Rattus novergicus) male. The study involved 4 groups, K0 was the control group, while the other (K1,K2,K3) was the case group with exposure of Cd in different concentration. For analyzing of the data, SPSS software version 17 was used and was examined by ANOVA test. The resulted showed that there are a significance differences of MDA, H
2O
2, SOD activity and AOPP between case and control group, but there are not MG and CC are not sgnificance differences. Our study showed Cd induced oxidative stress but not caused glycation reaction.
Index Terms—AOPP, cadmium, glycation and oxidative stress.
Eko Suhartono is with Environmental Science and Technology Graduate Program, University of Brawijaya, Malang, Indonesia and Medical Chemistry/Biochemistry Department Faculty of Medicine University of Lambung Mangkurat, Banjarmasin, Indonesia (e-mail: ekoantioxidant@gmail.com).br /> Triawanti is with Medical Chemistry/Biochemistry Department, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, Indonesia (e-mail: tria_fkunlam@yahoo.co.id).br /> Amin Setyo Leksono and M. Sasmito Djati are with the Biology Department, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia (e-mail: leksono72@yahoo.com; msdjati@ub.ac.id).
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Cite: Eko Suhartono, Triawanti, Amin Setyo Leksono, and M. Sasmito Djati, "Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium," International Journal of Chemical Engineering and Applications vol. 5, no. 6, pp. 497-501, 2014.
