General Information
    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Mr. Ron C. Wu
    • Abstracting/ Indexing: Chemical Abstracts Services (CAS), Ulrich's Periodicals Directory, CABI, Electronic Journals Library, Google Scholar, ProQuest, and Crossref
    • E-mail:
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Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan

IJCEA 2015 Vol.6(2): 75-80 ISSN: 2010-0221
DOI: 10.7763/IJCEA.2015.V6.455

Polarographic Methods for Determination of Ascorbic Acid in Pharmacetical Preparations

Swaroopa Rani N. Gupta
Abstract—Ascorbic acid is determined polarographically present in various types of medicinal samples by internal standard addition method. Potassium hydrogen phthalate buffer (pH 4.0) containing 0.25% oxalic acid and 0.008 % gelatin solution used as supporting electrolytes and maxima suppressor. Presence of colouring matters does not interfere, and sample handling and solution preparation for analysis can be carried out sufficiently fast to prevent appreciable oxidation. Polarographic determination of ascorbic acid can be carried out even in presence of comparable amounts of other ingredients such as Vitamins A, B, C, D, and E.
   Results of estimation of ascorbic acid present in different multivitamin medicinal samples by internal standard addition method obtained are in good agreement with the quoted values. The method is precise as indicated by low values of standard deviation.
   Comparative study of ascorbic acid estimation by polarographic internal standard addition method with respect to their manufacturing company was also done.

Index Terms—Ascorbic acid, internal standard addition method, medicinal samples, polarographic determination.

Swaroopa Rani N. Gupta is with the Department of Chemistry, Brijlal Biyani Science College Amravati, Maharashtra, India (e-mail:


Cite: Swaroopa Rani N. Gupta, "Polarographic Methods for Determination of Ascorbic Acid in Pharmacetical Preparations," International Journal of Chemical Engineering and Applications vol. 6, no. 2, pp. 75-80, 2015.

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