General Information
    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Mr. Ron C. Wu
    • Abstracting/ Indexing: Chemical Abstracts Services (CAS), Ulrich's Periodicals Directory, CABI, Electronic Journals Library, Google Scholar, ProQuest, and Crossref
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Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan

IJCEA 2015 Vol.6(2): 115-119 ISSN: 2010-0221
DOI: 10.7763/IJCEA.2015.V6.463

Optimization of Subcritical Ethanol Extraction for Xanthone from Mangosteen Pericarp

Nuttawan Yoswathana and M. N. Eshtiaghi
Abstract—Mangosteen pericarp has been used for long time as traditional medicine. One of main active ingredient in mangosteen pericarp is xanthone. Xanthone has remarkable effects on cardiovascular, antiviral, and anti-inflammatory. Subcritical ethanol extraction (Sc-ethanol) was employed to extract xanthone from dried mangosteen pericarp and compared with maceration and soxhlet extraction. The Sc-ethanol was applied by various temperature (80, 120 and 160oC), ethanol concentration (50, 72.5 and 95%) and extraction time (10, 20 and 30 min.) for 1:20 of sample to solvent ratio. The Box-Behnken design was applied to investigate the optimum condition of Sc-ethanol extration. The optimum conditions from Box-Behnken design to obtain the highest xanthone were determined at the optimum conditions as following; temperature 160oC, extraction time 30 min in 95% ethanol. The results presented that for maceration, soxhlet and Sc-ethanol extractions in 0.5 h, the extracted xanthones were 28.31, 31.26 and 57.42 mg/g of dried mangosteen pericarp respectively.

Index Terms—Mangosteen pericarp, maceration, soxhlet, subcritical ethanol extraction, xanthone.

N. Yoswathana and M. N. Eshtiaghi are with the Department of Chemical Engineering, Faculty of Engineering, Mahidol University, Salaya, Phuthamonthol ampur, Nakornprathom Province, Thailand 73170 (corresponding author: N. Yoswathana; e-mail:, mohamman.esh@


Cite: Nuttawan Yoswathana and M. N. Eshtiaghi, "Optimization of Subcritical Ethanol Extraction for Xanthone from Mangosteen Pericarp," International Journal of Chemical Engineering and Applications vol. 6, no. 2, pp. 115-119, 2015.

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