Abstract—Sampaguita (Jasminum sambac L.) crude leaf extracts had been known to possess anti-inflammatory properties. The study was conducted to determine the antiinflammatory property of the formulated topical gel from the extract of Sampaguita, Jasminum sambac Linn. (Family: Oleaceae) against 1% diclofenac emugel as positive control. The leaves of Sampaguita were collected in San Pedro, Laguna, Philippines. The collected leaves were subjected to Soxhlet apparatus with 80% methanol as solvent. The extract was concentrated with the use of Rotary evaporator and was lyophilized. The extract obtained was used for the formulation of the different concentration of topical gel. Color, homogenicity, consistency, phase separation, pH, and viscosity were performed to characterize the formulated gel. Carageenan-induced paw edema was used as the method in the evaluation of anti-inflammatory activity of the different concentrations of the formulated gel. The phlogistic agent, carrageenan, was used to induce the inflammation on the right hind paw of Sprague-Dawley rats. The foot volume measurement was obtained with the used pletysmometer as the mean of inflammatory measurement. Evaluating the different gel formulation if it is tolerable patch and scratch was carried out. Lastly, based on the three trials done on the antiinflammatory activity evaluation using One-Way Analysis of Variance (ANOVA) and a follow-up Tukey test, the Jasminum sambac Linn. leaves' extract retained its anti-inflammatory property in the formulated topical gel and have proven their worth as an anti-inflammatory agent.
Index Terms—Anti-inflammatory, pletysmometer, Sampaguita, Soxhlet apparatus.
Yvonne Mae C. Belango, Arlene F. Cruz, Rhoda B. Miguel, and Chad Rilyn L. Rotairo are with Adamson University, Ermita, Manila, Philippines.
Riel Anthony T. Oli is with Adamson University, Ermita, Manila, Philippines. He is also with the the University of Santo Tomas, España, Manila, Philippines (e-mail: rielanthonyoli@gmail.com).
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Cite: Yvonne Mae C. Belango, Arlene F. Cruz, Rhoda B. Miguel, Chad Rilyn L. Rotairo, and Riel Anthony T. Oli, "Anti-inflammatory Property of the Formulated Topical Gel from the Crude Leaf Extracts of Sampaguita (Jasminum sambac L. Family: Oleaceae)," International Journal of Chemical Engineering and Applications vol. 7, no. 3, pp. 199-203, 2016.
