Abstract—An efficient method for the asymmetric synthesis of enantiomerically enriched derivatives of (S)-propargylglycine by С-alkylation of NiII-complex of Schiff’s bases of propargylglycine and chiral auxiliary (S)-2-N-[N’-(benzylprolyl) amino] benzophenone with benzyl bromide and its derivatives (de 85-90 %) has been developed. This resulted in synthesis of new enantiomerically enriched α-amino acids containing acetylenic bond in the side chain (ee >95%).
Index Terms—Asymmetric synthesis, enantiomerically enriched α-amino acid, acetylenic bond.
Ashot. S. Saghyan, Anna F. Mkrtchyan, Ani J. Karapetyan, and Hayarpi M. Simonyan are with the SPC “Armbiotechnology” SNPO NAS RA, and is with chair the Pharmchemistry and Pharmacognosy of Yerevan State University, Republic of Armenia (e-mail: saghyan@netsys.am, anna_mkrtchyan@ysu.am, paruhiani@mail.ru, hayarpi@yandex.ru).
Z. Z. Mardiyan and L. A. Hayriyan are with the SPC “Armbiotechnology” SNPO NAS RA, Republic of Armenia (e-mail: zmardiyan@mail.ru, lianahayriyan@mail.ru).
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Cite: Ashot. S. Saghyan, Anna F. Mkrtchyan, Ani J. Karapetyan, Zorayr Z. Mardiyan, Liana A. Hayriyan, and Hayarpi M. Simonyan, "Synthesis of Enantiomerically Enriched Amino Acids Containing Acetylenic Bond in the Side-Chain Radical vol. 7, no. 6, pp. 413-416, 2016.
