General Information
    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Mr. Ron C. Wu
    • Abstracting/ Indexing: Chemical Abstracts Services (CAS), Ulrich's Periodicals Directory, CABI, Electronic Journals Library, Google Scholar, ProQuest, and Crossref
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Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan

IJCEA 2016 Vol.7(6): 433-436 ISSN: 2010-0221
doi: 10.18178/ijcea.2016.7.6.620

Process Intensification in Tiopronin Extraction

Zhigang Tang, Zhimin He, Hongwei Li, Dong Guo, and Zhijun Zhao
Abstract—In order to reduce the loss of ethyl acetate during tiopronin extraction, counter-current extraction is presented to replace the conventional cross-current extraction, as a process intensification strategy. Firstly the distribution coefficient of tiopronin between ethyl acetate and aqueous phase is determined. Next a calculation of counter-current extraction is done based on Matlab procedure. By the results, to achieve the effect of current production, it will save more than 60% extractant dosage by making use of 3-stage counter-current extraction. Moreover the conversion degree will increase three times replacing cross-current extraction by counter-current extraction.

Index Terms—Tiopronin, ethyl acetate, extraction, process intensification, conversion degree.

Zhigang Tang, Zhimin He, Hongwei Li, Dong Guo, and Zhijun Zhao are with State Key Laboratory of Chemical Engineering, Chemical Engineering Department, Tsinghua University, Beijing 100084 China (e-mail:,,,,


Cite: Zhigang Tang, Zhimin He, Hongwei Li, Dong Guo, and Zhijun Zhao, "Process Intensification in Tiopronin Extraction," International Journal of Chemical Engineering and Applications vol. 7, no. 6, pp. 433-436, 2016.

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