General Information
    • ISSN: 2010-0221
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Mr. Ron C. Wu
    • Abstracting/ Indexing: Chemical Abstracts Services (CAS), Ulrich's Periodicals Directory, CABI, DOAJ, Electronic Journals Library, Google Scholar, ProQuest, and Crossref
    • E-mail: ijcea@ejournal.net
  • Dec 06, 2017 News! Vol.8, No.6 has been published with online version. 9 peer reviewed papers are published in this issue.   [Click]
  • Oct 16, 2017 News! The papers published in Vol.8, No.4-5 have all received dois from Crossref.
Editor-in-chief
Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan
 

IJCEA 2017 Vol.8(3): 233-236 ISSN: 2010-0221
doi: 10.18178/ijcea.2017.8.3.662

Synthesis of Imidazole and Indole Hybrid Molecules and Antifungal Activity against Rice Blast

Tomio Sumiya, Mai Ishigaki, and Keimei Oh
Abstract—Azole and indole are parent substances of many natural and synthetic compounds with significant biological activity. However, the biological activity of the indole and azole conjugates are lack of investigation. In the present work, a series of hybrid molecules with imidazole and indole moiety were designed by using camalexin as a molecular scaffold. Compounds with different length of the carboxylic acid (4a-4f) were prepared. The antifungal activity of this synthetic series together with the ethyl esters analogues (3a-3f) against Magnaporthe oryzae were determined by using agar cup plate assay. Data obtained from the structure-activity relationship studies indicated that the ester analogues displayed antifungal activity against Magnaporthe oryzae while the carboxylic acid derivatives did not. This result indicated that the carboxylic acid ethyl ester moiety is important to antifungal activity. Among all the synthesized compounds, we found that, at a concentration of 100 M, compound 3c displays the most potent inhibition activity with 38.8±2.5% on the inhibition of the diameter of the mycelial mat of Magnaporthe oryzae while the positive control of propiconazole (10 M) was found 39.3±2.9%.

Index Terms—Antifungal activity, imidazole, indole, rice blast.

The authors were with the Department of Biotechnology, Akita Prefectural University, 241-438, Shimoshinjo Nakano Akita-Shi, Akita 010-0195 Japan (e-mail: K.O. e-mail: jmwang@akita-pu.ac.jp).

[PDF]

Cite: Tomio Sumiya, Mai Ishigaki, and Keimei Oh, "Synthesis of Imidazole and Indole Hybrid Molecules and Antifungal Activity against Rice Blast," International Journal of Chemical Engineering and Applications vol. 8, no. 3, pp. 233-236, 2017.

Copyright © 2008-2015. International Journal of Chemical Engineering and Applications. All rights reserved
E-mail: ijcea@ejournal.net