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    • ISSN: 2010-0221 (Print)
    • Abbreviated Title: Int. J. Chem. Eng. Appl.
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    • DOI: 10.18178/IJCEA
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National Taipei University of Technology, Taiwan
 

HOME > Archive > 2017 > Volume 8 Number 4 (Aug. 2017) >
IJCEA 2017 Vol.8(4): 290-293 ISSN: 2010-0221
doi: 10.18178/ijcea.2017.8.4.672

Schiff Base Dinuclear Zn(II) Complexes as Assisting Fluorescent Probe for CD19 Antibody Protein

Sae Yasuda, Masahiro Takase, Atsuko Sano, and Takashiro Akitsu

Abstract—In immunity functional tests with flow cytometry, proteins emerging surface or inner part of lymphocytes are analyzed with the aid of fluorescent emission generally. In this study, we employed newly prepared Schiff base binuclear Zn(II) complexes instead of commercially available fluorescent labeling agents to improve intensity of fluorescence. According to UV-vis, fluorescent, and flow cytometry measurements, X-ray crystallography, and in-silico docking simulation (GOLD), it can remarkably enhance fluorescent intensity for CD19 antibody without specific binding to CD19.

Index Terms—Zinc(II) complex, schiff base, CD19, fluorescent, flow cytometry.

The authors are with the Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan (e-mail: akitsu@rs.kagu.tus.ac.jp).

[PDF]

Cite: Sae Yasuda, Masahiro Takase, Atsuko Sano, and Takashiro Akitsu, "Schiff Base Dinuclear Zn(II) Complexes as Assisting Fluorescent Probe for CD19 Antibody Protein," International Journal of Chemical Engineering and Applications vol. 8, no. 4, pp. 290-293, 2017.

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