Abstract—The application of new
109AgNPET nanoparticle surface for analysis of nucleosides and nucleic bases is described along with characterization of
109Ag nanoparticles. The nanoparticles allow laser desorption-ionization mass spectrometry analyses of various low molecular weight (LMW) organic compounds. The new method was used for successful determination of thymidine, 5-fluorouracil, 2’-deoxycytidine, cytidine and 2’-deoxyuridine. The mass determination accuracy was in the 1-3 mDa range which confirms identity of the analyte.
Index Terms—Low molecular weight compounds, MALDI, mass spectrometry, matrix-assisted laser desorption-ionization, nanoparticles, SALDI.
The authors are with the Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland (e-mail: tomruman@prz.edu.pl).
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Cite:Joanna Nizioł and Tomasz Ruman, "Silver 109Ag Nanoparticles for Matrix-Less Mass Spectrometry of Nucleosides and Nucleic Bases," International Journal of Chemical Engineering and Applications vol. 4, no. 2, pp. 46-49, 2013.
