General Information
    • ISSN: 2010-0221 (Print)
    • Abbreviated Title: Int. J. Chem. Eng. Appl.
    • Frequency: Bimonthly
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Jennifer X. Zeng
    • Abstracting/ Indexing: Chemical Abstracts Services (CAS), Ulrich's Periodicals Directory, CABI, Electronic Journals Library, Google Scholar, ProQuest,  Crossref, EBSCO.
    • E-mail: ijcea@ejournal.net
  • Jul 12, 2019 News! The papers published in Vol.10, No.1-No. 4 have all received dois from Crossref.
  • Jun 21, 2019 News! Vol.10, No.4 has been published with online version. 7 peer reviewed papers are published in this issue.   [Click]
Editor-in-chief
Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan
 

IJCEA 2019 Vol.10(3): 69-74 ISSN: 2010-0221
doi: 10.18178/ijcea.2019.10.3.743

Synthesis and Characterization of Molecularly Imprinted Polymer for Prasugrel Drug Base on 2-Hydroxyethyl Methacrylate Monomer in Biological and Pharmaceutical Samples

Maryam Pyambri Pramani
Abstract—In this research work, a molecularly imprinted polymer (MIP) was synthesized for Prasugrel. In this method, a polymer was first synthesized using 2-hydroxyethyl methacrylate (HEMA) as a monomer, N, N’-methylenebisacrylamide as a crosslinker, and azobisisobutyronitrile (AIBN) as an initiator. The successful synthesis of the MIP was confirmed by elemental analysis (CHN), Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Then, the effects of various parameters such as pH, temperature, MIP capacity, selectivity, adsorption kinetics and adsorption isotherms were investigated by UV-Vis spectroscopy. The calibration curve was plotted for Prasugrel in these conditions and linear range, limit of detection (LOD) and limit of quantification (LOQ) were reported. Finally, the performance of the synthesized MIP as an adsorbent was studied under optimized conditions for the extraction and determination of Prasugrel in tablet matrix and biological fluids such as urine and plasma by high performance liquid chromatography (HPLC).

Index Terms—Prasugrel, molecular imprinting polymer, biological fluids, pharmaceutical sample.

The author is with Maryam Pyambri Pramani, Islamic Azad University, Iran (e-mail: maryampramani@gmail.com).

[PDF]

Cite: Maryam Pyambri Pramani, "Synthesis and Characterization of Molecularly Imprinted Polymer for Prasugrel Drug Base on 2-Hydroxyethyl Methacrylate Monomer in Biological and Pharmaceutical Samples," International Journal of Chemical Engineering and Applications vol. 10, no. 3, pp. 69-74, 2019.

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