Abstract—In this research work, a molecularly imprinted
polymer (MIP) was synthesized for Prasugrel. In this method, a
polymer was first synthesized using 2-hydroxyethyl
methacrylate (HEMA) as a monomer, N,
N’-methylenebisacrylamide as a crosslinker, and
azobisisobutyronitrile (AIBN) as an initiator. The successful
synthesis of the MIP was confirmed by elemental analysis
(CHN), Fourier-transform infrared (FT-IR) spectroscopy and
scanning electron microscopy (SEM). Then, the effects of
various parameters such as pH, temperature, MIP capacity,
selectivity, adsorption kinetics and adsorption isotherms were
investigated by UV-Vis spectroscopy. The calibration curve was
plotted for Prasugrel in these conditions and linear range, limit
of detection (LOD) and limit of quantification (LOQ) were
reported. Finally, the performance of the synthesized MIP as an
adsorbent was studied under optimized conditions for the
extraction and determination of Prasugrel in tablet matrix and
biological fluids such as urine and plasma by high performance
liquid chromatography (HPLC).
Index Terms—Prasugrel, molecular imprinting polymer,
biological fluids, pharmaceutical sample.
The author is with Maryam Pyambri Pramani, Islamic Azad University,
Iran (e-mail: maryampramani@gmail.com).
[PDF]
Cite: Maryam Pyambri Pramani, "Synthesis and Characterization of Molecularly Imprinted Polymer for Prasugrel Drug Base on 2-Hydroxyethyl Methacrylate Monomer in Biological and Pharmaceutical Samples," International Journal of Chemical Engineering
and Applications vol. 10, no. 3, pp. 69-74, 2019.
