Abstract—Mefenamic acid is one of the active pharmaceutical ingredientsthat exhibit polymorphism. An experimental study has found that Form I of mefenamic acid is produced fromcooling crystallization with ethanol as a solvent. Hydrogen bonding is considered as the fundamental factor that controls the polymorphism of mefenamic acid in ethanol. This work, in essence, was performed to verify this using molecular dynamics simulation.The simulation was performed using COMPASS force field available in Material Studio package.The resultof the simulation showed strong hydrogen bonding between oxygen and hydrogen in the carboxylic group.The results of the Fourier transform infrared spectroscopy analysis confirmed the existence of O-H, C-O and C=O bonds. These findings proved the presence of hydrogen bondsthat leads to the formation of hydrogen motif in Form I of mefenamic acid during crystallization process using ethanol as a solvent.
Index Terms—Radial distribution function, COMPASS, Ewald, polymorphs
Siti Kholijah Abdul Mudalip and Parveen Jamal are with the Kulliyyah of Engineering, International Islamic University Malaysia, 50728 Kuala Lumpur, Malaysia (e-mail: ctkhol@ yahoo.com, jparveen@ iium.edu.my).
Mohd. Rushdi Abu Bakar is with the Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia (e-mail: rushdi@iium.edu.my).
Fatmawati Adam is with the Chemical Engineering Department, Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia (e-mail: fatmawati@ump.edu.my).
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Cite:Siti Kholijah Abdul Mudalip, Mohd. Rushdi Abu Bakar, Fatmawati Adam, and Parveen Jamal, "Structures and Hydrogen Bonding Recognition of Mefenamic Acid Form I Crystals in Mefenamic Acid/ Ethanol Solution," International Journal of Chemical Engineering and Applications vol. 4, no. 3, pp. 124-128, 2013.
