Abstract—Cadmium (Cd) is a heavy metal that be a source of concern for industrial workers and it was proposed in the formation of advance glycation end products (AGEs) such as methylglyoxal (MG). In the other hand the exposure of Cd also induced the formation of Hydrogen Peroxide (H
2O
2), Carbonyl Compound (CC) and Advance Oxidation Protein Products (AOPP). The role of Cd in the formation of MG, H
2O
2, CC and AOPP in ovarian has not been much studied. Thus, our study aims to measure the formation rate of MG, H
2O
2, CC and AOPP in ovarian rat. Female Rattus novergicus was divided in two groups, one control groups and one case group. Furthermore we set MG, CC, H
2O
2 and AOPP as a biomarker of ovarian cell damage. For analyzing of the data, SPSS software version 17 was used and was examined by Mean-Whitney test. For all outcomes, a nominal p-value of
p<0,05 was considered significant. The resulted showed that there are a significance differences of MG, CC, H
2O
2 and AOPP between case and control group.
Index Terms—AOPP, cadmium, hydrogen peroxide, and methylglyoxal.
The authors are with Faculty of Medicine Lambung Mangkurat University South Kalimantan, Indonesian (e-mail: annisa_halida@rocketmail.com, earahmadhani@gmail.com, evadamay antitumbelaka@rocketmail.com, alvitayulita@ymail.com, ekoantioxidant @gmail.com).
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Cite: A. H. Husna, E. A. Ramadhani, Eva D. T., A. F. Yulita, and E. Suhartono, "The Role Formation of Methylglyoxal, Carbonyl Compound, Hydrogen Peroxide and Advance Oxidation Protein Product Induced Cadmium in Ovarian Rat," International Journal of Chemical Engineering and Applications vol. 5, no. 4 pp. 319-323, 2014.
