Abstract—In the present study, newer chalcones and flavonols were synthesized by Algar-Flynn-Oyamada method, purified and characterized by spectral methods. The pure test compounds were evaluated for in vitro antioxidant activity using four models namely 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•), Nitric oxide (NO) and Lipid Peroxidation scavenging methods. This study indicate that, amongst the ten evaluated chalcones and flavones, five test compounds showed activity with IC50 value lesser than that of the standard ascorbic acid at 91.21 μM for 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging.
Index Terms—Antioxidant, Chalcones, Flavonols.
Venkatachalam H. is with Department of Chemistry, Kasturba Medical College International Center, Manipal University, Manipal, India (e-mail: venkatachalam.h@manipal.edu).
Yogendra Nayak is with Pharmacology, Manipal College of Pharmaceutical Sciences University, India
B. S. Jayashree is Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences University, India
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Cite: Venkatachalam H., Yogendra Nayak, and B. S. Jayashree, "Evaluation of the Antioxidant Activity of Novel Synthetic Chalcones and Flavonols," International Journal of Chemical Engineering and Applications vol. 3, no. 3, pp. 216-219, 2012.
