Department of Healthcare Administration, Asia Eastern University of Science and Technology, New Taipei City, Taiwan
Email: yhlai1108@gmail.com (Y.L.); fl005@mail.aeust.edu.tw (F.F.H.)
*Corresponding author
Manuscript received May 7, 2024; revised June 4, 2024; accepted July 17, 2024; published November 27, 2024
Abstract—Detecting early indications of lung cancer is challenging, resulting in delayed identification and advanced stage diagnoses for most patients. Conventional diagnostic approaches for lung cancer face issues such as low accuracy, missed diagnoses, and misinterpretations. Consequently, there is a growing recognition of the crucial role early detection plays in managing lung cancer. This study aimed to explore the correlation between blood type and lung cancer through the analysis of real-world data. The goal is to improve public awareness of the significant risks associated with lung cancer, promote active engagement in relevant screenings, and underscore the importance of early detection, timely treatment, and overall well-being restoration, particularly for individuals with an elevated risk. Utilizing the TriNetX database, the research performed a real-world analysis of data to investigate the correlation between ABO blood groups and the risk of lung cancers. The lung cancer risk ratio between blood types A and AB is 0.934 (95% CI: 0.876–0.996). Blood type A patients have a 12-year cumulative incidence rate of 1.710%, while blood type B patients have a rate of 1.823%. The risk ratio of lung cancer for blood type B vs. AB is 0.918 (95% CI: 0.861–0.979). The 12-year cumulative incidence rate for blood type B patients is 1.683%, and for blood type AB patients, it is 1.823%. There were no statistically significant differences in the risk ratios for all other groups. The findings of this study suggest that individuals with blood type AB face an elevated risk of developing lung cancer in comparison to those with blood type A. Moreover, individuals with blood type AB exhibit a greater susceptibility to lung cancer when contrasted with individuals having blood type B.
Keywords—ABO blood types, respiratory system cancer, lung cancer, real-world data
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Cite: Yi-Horng Lai and Fen-Fen Huang, "ABO Blood Groups and Risk of Lung Cancer: A Retrospective Cohort Study Using Electronic Health Record," International Journal of Chemical Engineering and Applications vol. 15, no. 2, pp. 64-70, 2024.
