General Information
    • ISSN: 2010-0221 (Print)
    • Abbreviated Title: Int. J. Chem. Eng. Appl.
    • Frequency: Biannually
    • DOI: 10.18178/IJCEA
    • Editor-in-Chief: Prof. Dr. Shen-Ming Chen
    • Executive Editor: Alice Loh
    • Abstracting/ Indexing:  CNKI, Google Scholar, EBSCO, ProQuest,  Crossref, etc.
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Prof. Dr. Shen-Ming Chen
National Taipei University of Technology, Taiwan

IJCEA 2016 Vol.7(5): 289-294 ISSN: 2010-0221
doi: 10.18178/ijcea.2016.7.5.591

Solubility of Nutraceutical Compounds in Generally Recognized as Safe Solvents at 298 K

Remil Aguda and Chau-Chyun Chen

Abstract—The solubility of two model nutraceuticals, quercetin and sclareol, were measured in organic solvents at 298 K by UV-Vis spectrophotometry and gas chromatography, respectively. Thermodynamic models for solid-liquid phase equilibria are used to correlate and predict the solubility of quercetin and sclareol in organic solvents which are Generally Recognized as Safe by the United States Food and Drug Administration. For both quercetin and sclareol, the NRTL-SAC model satisfactorily correlates the experimental data while the COSMO-SAC solubility prediction results are off by more than one natural logarithm of mole fraction of the experimental data.

Index Terms—Generally recognized as safe solvents nutraceutical, NRTL-SAC, quercetin, sclareol, solubility, COSMO-SAC.

Remil Aguda was with the Institute of Chemistry, University of the Philippines Los Baños Laguna Philippines 4031 and Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA (e-mail:
Chau-Chyun Chen is with the Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA (e-mail:


Cite: Remil Aguda and Chau-Chyun Chen, "Solubility of Nutraceutical Compounds in Generally Recognized as Safe Solvents at 298 K," International Journal of Chemical Engineering and Applications vol. 7, no. 5, pp. 289-294, 2016.

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